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KMID : 0980720160350020133
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Keimyung Medical Journal
2016 Volume.35 No. 2 p.133 ~ p.139
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Relapsing Polychondritis Showing Personality Changes and Cognitive Impairment
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Lee Ji-Min
Lee So-Yeon
Park Myung-Soon
Lee Ye-Yeon
Kim Ji-Min
Kim Sang-Hyun
Son Chang-Nam
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Abstract
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Relapsing polychondritis is a rare, multisystem autoimmune disease. It is characterized by recurrent inflammation of the cartilage and connective tissues in the body. In this paper, we described a case of relapsing polychondritis initially presented symptoms of cognitive dysfunction and personality changes. A 63-year-old male reprented fever, cognitive impairment and personality changes. Brain magnetic resonance imaging revealed leptomeningeal and periauricular hyperintensities. A cerebrospinal fluid examination showed aseptic meningitis. As he reprented hearing difficulties, audiometry showed the sensory neural hearing loss. On physical examination, erythematous swollen auricles were noted. Auricle biopsy consisted with inflammation with perichondritis. He was diagnosed with relapsing polychondritis accompanied by leptomeningeal meningitis, and treated with methylprednisolone (62.5 mg/day for 3 days) followed by prednisolone 60 mg/day and methotrexate 7.5 mg/week. Fever and painful swellings on the both ears subsided. He showed improvement in cognitive function and personality. Although relapsing polychondritis is rare, it should be considered to be a possible cause of leptomeningeal meningitis.
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KEYWORD
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Cognitive impairment, Leptomeningeal meningitis, Personality changes, Relapsing polychondritis
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